In inflammatory response, absence of which one of following would prevent all ors from happening?

Histamine, biologically active substance found in a great variety of living organisms. It is distributed widely. The effect histamine has on blood vessels is crucial to its role in the immune response, which is most clearly observed in inflammation i.e., the local reaction of bodily tissues to injury caused by physical damage, infection, or allergic reaction. Injured tissue mast cells  release histamine, causing the surrounding blood vessels to dilate and increase in permeability. This allows fluid and cells of the immune system, such as leukocytes (white blood cells) and blood plasma proteins, to leak from the bloodstream through the vessel walls and migrate to the site of tissue injury or infection, where they begin to fight the infection and nourish and heal the injured tissues..

So, the correct option is 'Option A'.