$\text{Correct option: }$ A

$\text{ Solution: }$

$\text{ Option (A): }$

$?$The  biogeographic region showing presence of a significant level of biodiversity  that is threatened by human habitation and destructive activities, is defined as a biodiversity hotspot. 

$?$This area shows less interspecific interaction or particularly competition of species. 

$\text{ Option (B): }$

$?$Species richness (S) is considered as number of species within a defined region. 

$?$This factor is considerate in ecological area, specifically a biodiversity hotspot. 

$\text{ Option (C): }$

$?$Endemism is state of a species which is a native of a particular geographic location. 

$?$These species are not found anywhere else or any or geographic area. 

$\text{ Option (D): }$

$?$The destructive human activity such as increasing pollution, overexploitation,habitat loss, and introduction of invasive species brings in global extinction or biodiversity loss. 

$?$This biodiversity loss is actually correlated with accelerated loss of species. 

Hence, correct option is (A).